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P&O do have wheelchair accessible cabins, including bathroom. These are slightly larger than normal and have wider electrically operated doors. These are indicated on the deckplans but they do get booked up quickly. They also have wheelchair accessible transport at certain ports, usually those within the EU, although they are dependent on local availabilty. Many people inwheelchairs cruise and do not seem to have a problem. Mosy of the other major cruise lines offer the same facilities, particularly on modern ships.
I am not aware of one that does not offer full facilities for wheelchair users and most are very good at making sure that your experience is no different to that of able bodied people. There will be the odd occasion when certain excursions will not be available because the places involved do not offer full access etc. and there may be times when going onto the ship's tender is not practicable, this occurs when the ship is anchored off-shore and the sea is running in a dangerous manner. Hope that helps. .... Neil.